计算机辅助疫苗设计英文版 Computer-aided vaccine design

leehwadong

Contents
List of figures xi
List of abbreviations xv
About the authors xxi
Preface xxv
1 MHC and T cell responses 1
1.1 Genetic organization of the MHC 2
1.2 MHC structure 3
1.3 MHC function 5
1.4 Peptide binding 8
1.5 Bibliography 9
2 Immunoglobulins and B cell responses 13
2.1 Types of immunoglobulins 14
2.2 Immunoglobulin structure 15
2.3 Immunoglobulin function 17
2.4 Antigen binding 19
2.5 Bibliography 19
3 Scientifi c publications and databases 21
3.1 Bibliographical information 22
3.2 Searching the literature 23
3.3 General databases containing information
on genes and proteins 25
3.4 Immunological databases 29
3.5 Small molecule databases 39
3.6 Bibliography 42
4 Database design 47
4.1 Fundamentals of database design 48
4.2 ER diagram 50
4.3 Normalization and normal forms 54
4.4 Bibliography 57
5 Computational T cell vaccine design 59
5.1 Sequence-based methods 60
5.2 Structure-based methods 70
5.3 Broad-based T cell vaccine design 74
5.4 Bibliography 76
6 Computational B cell vaccine design 87
6.1 Sequence-based methods 88
6.2 Structure-based methods 91
6.3 Bibliography 94
7 Infectious disease informatics 99
7.1 Infectious diseases in history 100
7.2 Microbial sequence analysis 101
7.3 Detecting natural selection in molecular evolution 105
7.4 Bibliography 107
8 Vaccine safety and quality assessments 111
8.1 Assessment of ADME/Tox defi ciencies 112
8.2 Assessment of allergenicity 114
8.3 Bibliography 116
9 Vaccine adjuvant informatics 123
9.1 Virtual combinatorial library 124
9.2 Chemical fi le formats 125
9.3 Considerations for virtual library design 126
9.4 Bibliography 127
Index 131

小洁

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胜利者

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