消毒剂的轮替使用

beiwei5du · 发表于 2017-1-14 23:24:57

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本帖最后由 beiwei5du 于 2017-1-14 23:34 编辑

消毒剂的轮替使用
The rotation of an effective disinfectant with a sporicide is encouraged. It is prudent to augment the daily use of a bactericidal disinfectant with weekly (or monthly) use of a sporicidal agent. The daily application of sporicidal agents is not generally favored because of their tendency to corrode equipment and because of the potential safety issues with chronic operator exposure. Other disinfection rotation schemes may be supported on the basis of a review of the historical environmental monitoring data. Disinfectants applied on potential product contact surfaces are typically removed with 70% alcohol wipes. The removal of residual disinfectants should be monitored for effectiveness as a precaution against the possibility of product contamination.

MICROBIAL RESISTANCE TO DISINFECTANTS

The development of microbial resistance to antibiotics is a well-described phenomenon. The development of microbial resistance to disinfectants is less likely to occur at significant levels, as disinfectants are more powerful biocidal agents than antibiotics. In addition, they are normally applied in high concentrations against low populations of microorganisms usually not growing actively, so the selective pressure for the development of resistance is less profound. However, the most frequently isolated microorganisms from an environmental monitoring program may be periodically subjected to use-dilution testing with the agents used in the disinfection program to confirm their susceptibility, as there are real differences among different species in resistance to the lethal effects of different sanitizers.

选自：

1072

DISINFECTANTS AND ANTISEPTICS

The Rotation of Disinfectants Principle: True or False?
http://www.pharmtech.com/rotatio ... ciple-true-or-false

syhorchid · 发表于 2017-1-14 23:49:13

学习一下

cts9166 · 发表于 2017-1-15 07:22:23

想进来学习和参与讨论的，现在行业普遍是随机或定期使用不同的消毒剂，估计也只能这样执行，否则会有法规风险

scslk0045 · 发表于 2017-1-15 07:30:19

讲的很好，学习了

抗生素制造者 · 发表于 2017-1-15 07:45:05

水平不济，看不懂

玻璃杯 · 发表于 2017-1-15 08:51:32

我们目前是采用：不同消毒剂和杀孢子剂联合使用，不过没有对过往的监控数据进行分析，只是理论上认为应该多种类循环使用。因为夏天阴雨季节的孢子风险明显要高于日常的。

晴空万里5566 · 发表于 2017-1-15 13:44:01

水平不济，看不懂

jixia · 发表于 2019-11-23 16:35:11

学习了

yanyhq · 发表于 2019-11-25 11:22:17

酸、碱交替使用

1280493605 · 发表于 2019-11-25 11:45:18

学习了，很受用

[质量保证QA] 消毒剂的轮替使用

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